Subcutaneous Administration
Injection into the subcutaneous fatty tissue is an important route of administration for many substances such as insulin or antibodies. The formation of drug depots in adipose tissue and drug distribution are crucial for assessing absorption into the blood, pharmaceutical effects or possible side effects.
Ex-vivo PK Testing in Adipose Tissue
We investigate and compare drug transport in subcutaneous adipose tissue.
Preclinical Studies in Adipose Tissue
Ex-vivo experiments are carried out with freshly removed human and animal tissues.
Clinical Studies in Adipose Tissue
In-vivo clinical assessment of PK/PD profiles in healthy volunteers or patients.
Additional expertise
- Combination of microdialysis and OFM technologies for protein binding studies.
- Testing and optimization of injection devices: Use of live in vivo imaging techniques (e.g. µCT) to visualize an injected substance depot directly in the tissue.
- Various glucose clamping techniques (hypo-, hyper-, eugylcemia) to determine the glucose infusion rate, insulin initiation time,...
- Studies with isotope-labeled insulins for monitoring glucose metabolism (endogenous glucose production and peripheral glucose uptake)
