Metabolomics

We conduct untargeted metabolomics studies and targeted quantification of metabolites to investigate metabolic processes.

 

 

 

 

We pool our bio-analytical, statistical, medical, biological and biochemical expertise and combine it with advanced information technology. This strategy allows us to offer a wide range of customer-oriented services in the field of metabolomics and metabolic research.

Untargeted metabolomics and targeted quantification of metabolites

 

We provide a wide range of metabolomics services on targeted and untargeted analytical platforms. Our expertise comprises the correct choice of sample types, sample collection procedures, sample storage and delivery, sample preparation in combination with the best metabolomics platforms. Furthermore, data processing and statistical analysis methods are well established .

  • Metabolites of primary metabolism (amino acids, Krebs cycle, glycolysis, pentosephosphate pathway, CoAs, …)
  • Energy metabolism
  • Metabolite fingerprinting
  • Quantification of coenzyme-A activated compounds
  • Quantification of spermidine and relatives (polyamines)
  • Stable isotope labelling (SIL) supported metabolomics

Our Expertise

 

We provide flexible, solutions tailored to your needs and cover the complete study or only single steps ranging from support in study design, data generation (extraction, targeted/untargeted measurement) to analysis (feature detection, normalization, quality control, corrections, identification), interpretation (visualization, uni-/multi/-variate statistics) to knowledge generation (experienced scientists).

  • Sample preparation        
  • Data processing: visualization, filtering and correction
  • Metabolite identification
  • Univariate and multivariate statistical methods
  • Sample types: muman, mouse, rat, pig, drosophila and a wide variety of microbial species and cell cultures

Selected metabolomics studies

 

Title

Authors

Metabolic phenotyping of first degree relatives of patients with type 1 diabetes.

Zügner E, presented at EASD 2017

N-acetylaspartate catabolism determines cytosolic acetyl-coa levels and histone acetylation in brown adipocytes.

Prokesch A, et al. Sci Rep. 2016, 6:23723.

Accumulation of basic amino acids at mitochondria dictates the cytotoxicity of aberrant ubiquitin.

Braun RJ, et al Cell Rep. 2015 ,10(9):1557-1571.

Targeting the H3K4 demethylase KDM5B reprograms the metabolome and phenotype of melanoma cells.

Vogel FCE, et al. J Invest Dermatol. 2019, 139(12):2506-2516.e10.

Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication.

Fröhlich E, Brain Behav Immun. 2016, 56:140-55.

Identification of novel metabolic interactions controlling carbon flux from xylose to ethanol in natural and recombinant yeasts.

Trausinger G, et al Biotechnol Biofuels. 2015, 25;8:157.

Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis.

Duta-Mare M, et al Biochim Biophys Acta Mol Cell Biol Lipids. 2018, 1863(4):467-478.

Differential effects of SGLT2 inhibitors on mitochondrial oxidative phosphorylation, glucose uptake, cell energy level and metabolism in HEPG2 cells and HUVECS.

Zügner E, presented at EASD 2020

Cardioprotection and lifespan extension by the natural polyamine spermidine.

Eisenberg T, et al Nat Med. 2016, 22(12):1428-1438.

Webinar

Join our experts on 1st June for selected analytical methods for diabetes and obesity research.

Contact Us

 

Learn more about Metabolomics

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our Metabolomics Experts.