Preclinical Studies Using Brain Xenocraft Tumor Models

Our Key Services Include:

• Atraumatic Tumor Access: Revolutionary cOFM-based approach providing direct access to functional tumor tissue without trauma generation, ensuring reliable and physiologically relevant data collection.
• Orthotopic Xenograft Development: Precise implantation of tumor cells into brain tissue with intact blood-brain barrier, creating clinically relevant tumor models that develop naturally at the probe-tissue interface.
• High Success Rate Models: Proven methodology achieving consistently high tumor development success rates (>70%), ensuring efficient study execution and reliable experimental outcomes.
• Intact Microenvironment Preservation: Maintenance of physiological tumor microenvironment conditions, allowing for accurate assessment of drug penetration, efficacy, and biomarker expression in realistic tissue conditions.
• Real-Time Tumor Monitoring: Continuous sampling of interstitial fluid from functional tumor tissue in vivo, enabling dynamic assessment of therapeutic responses and biomarker changes over time.
• Comparative Model Validation: Comprehensive characterization of cOFM-induced tumors alongside traditional injection methods, ensuring model validity and translational relevance for human applications.
• BBB-Intact Tumor Studies: Investigation of blood-brain barrier function within intact tumor tissue, providing critical insights for CNS drug development and understanding of tumor-BBB interactions.

Our advanced methodology delivers unprecedented access to functional tumor tissue while preserving physiological conditions, enabling reliable data generation for drug research, biomarker identification, and therapeutic development in oncology.