Our animal models include healthy and disease models (e.g., diabetes) in rodents and pigs. Preclinical in-vivo studies are performed in cooperation with the Institute for Biomedical Research at the Medical University of Graz.
We investigate intended effects of your drug and potential side effects directly in subcutaneous tissue by applying a formulated drug via the intended route (e.g. subcutaneous, oral, topical). We use adipose OFM probes in the dermis and continuously sample interstitial fluid. Multiple probes per application site allow for an efficient study design which delivers a large amount of reliable data while using only a relatively small number of subjects in PK/PD studies.
Complementary techniques include in-vivo biopsies to obtain cross-sectional PK profiles.
Learn more about our Preclinical Study Sercices
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our experts: croservices@joanneum.at