Ex-vivo PK Testing in Adipose Tissue

We use freshly explanted human and porcine tissue samples to investigate and compare subcutaneous drug delivery and distribution. Ex-vivo studies are ideal to simultaneously test the penetration rates of many different formulations. The lack of blood circulation generates higher drug concentrations even for less effective formulations and also allows for multiple drug applications on one sample. Ex-vivo studies are cost effective and compliant with the 3R strategy to reduce animal testing.