Bioanalysis and Metabolomics Laboratory

Bioanalyses for pharmacokinetic/phamacodynamic studies, metabolomics for clinical research and pharmaceutical analyses.

We are experts in the development and validation of analytical methods according to GLP/GCP standards. The focus is on chromatographic mass spectrometric methods and immunoassays.

Bioanalysis: 

Detection of biological or pharmaceutical substances in biological samples from clinical and preclinical studies: Our expertise lies in the detection of the lowest concentrations in the smallest sample volumes (µl).

Metabolomics: 

Specific (targeted) and broad (untargeted) metabolomics analyses for the determination and quantification of metabolites from metabolic processes for biomarker research 

Pharmaceutical Analysis: 

Active ingredient analysis for quality assurance of pharmaceutical production facilities, for the validation of cleaning processes (batch release), content determination, testing for impurities in pharmaceutical products

Instrumentation:

• HPLC-MS (high-resolution mass spectrometer)
  • UHPLC-Q-Exactive (Thermo Scientific®)
  • HPLC-LTQ Orbitrap XL (Thermo Scientific®)
• HPLC-MS/MS (triple quadrupole mass spectrometer)
  • Agilent 6495 Triple Quad UHPLC-MS/MS
  • Thermo Scientific(R) TSQ Quantum UHPLC-MS/MS 
  • Thermo Scientific(R) TSQ Quantum HPLC-MS/MS 
• GC-MS (triple quadrupole mass spectrometer)
  • GC-MS/MS: Agilent 7890A/7000B inkl CTC Pal Combi XT Autosampler
• HPLC-UV
  • Agilent 1290 Infinity 2 , DAD detector
  • Thermo Scientific®, UHPLC Vanquishe, UV detector 
• Robotic Liquid Handling Workstation: Hamilton® Microlab STARlet liquid handling system
• Reader: Microplate reader fluorescence, UV/VIS, (BioTek®)
• Multiplexing Immunoassay: MESO QuickPlex (Meso Scale Discovey®)
• IVRT Testing: Qualified 6-cell manual vertical diffusion cell system (Hanson Research Corporation)