Clinical studies range from investigator initiated studies and first-in-human studies to clinical stage phase 0 or phase 1 studies. We monitor local PK/PD directly in the subcutaneous adipose tissue for up to 72 hours using aOFM or microdialysis. Clinical studies can be conducted in healthy volunteers or patients (diabetes, obesity). Clinical trials are conducted according to ICH-GCP standards at the Clinical Trials Unit of the Medical University of Graz.
We investigate intended effects of your drug and potential side effects directly by applying a formulated drug via the intended route (e.g. subcutaneous, oral, topical). We use dOFM or microdialysis probes and continuously sample interstitial fluid. Multiple OFM probes allow for an efficient study design which delivers a large amount of reliable data while using only a relatively small number of subjects in PK/PD studies.
Samples are analyzed in our GLP certified lab for drug´s concentration and for a wide PD marker panel.
Learn more about our Clinical Study Sercices
Schedule a conversation with
our OFM experts: croservices@joanneum.at