Preclinical Studies in Blood Brain Barrier Research

Comprehensive in-vivo preclinical CNS real-time PK/PD profiling through advanced blood-brain barrier monitoring. From transport kinetics to biomarker dynamics – optimize your neurotherapeutic development with precision data.

 

 

 

 

Preclinical Studies in Blood Brain Barrier Research

Our comprehensive blood-brain barrier (BBB) research platform includes advanced monitoring capabilities across various animal models from mice and rats to primates. We provide cutting-edge solutions for pharmaceutical and biotechnology companies developing CNS-targeted therapeutics.

We investigate drug transport mechanisms, neuronal biomarker dynamics, and BBB integrity through real-time monitoring techniques. Our specialized approaches allow for precise measurement of substance concentrations in brain tissue and cerebrospinal fluid, providing critical insights into CNS drug development and neurological research.

 

Our Key Services Include
  • Substance Transport Monitoring: Real-time assessment of drug and compound transport across the intact blood-brain barrier, enabling precise evaluation of CNS penetration capabilities.
  • Neuronal Biomarker Analysis: Comprehensive monitoring of key neuronal biomarkers including leptin and tau-protein, with no limitations regarding molecular size or lipophilicity properties.
  • BBB Function Assessment: Detailed evaluation of blood-brain barrier integrity and permeability changes under various physiological and pathological conditions.
  • Time-Resolved Brain Monitoring: Continuous, time-dependent measurement of substance concentrations directly in brain tissue, providing dynamic pharmacokinetic profiles.
  • Multi-Site Brain Sampling: Simultaneous sampling capabilities across different brain regions, allowing for direct comparison between cerebrospinal fluid (CSF) and brain interstitial fluid (ISF) concentrations.
  • Versatile Animal Models: Studies conducted across a comprehensive range of animal models, from small rodents (mouse/rat) to non-human primates, ensuring translational relevance for human applications.

Our advanced methodologies deliver high-quality, reliable data while optimizing study efficiency and minimizing the number of subjects required for comprehensive PK/PD analyses in CNS research.

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More information

To learn more about our innovative technology and its application, please visit our dedicated OFM website.

Contact Us

 

Learn more about our Preclinical Study Sercices

Schedule a conversation with
our experts: croservices@joanneum.at