Our animal models include healthy and disease models (psoriasis, chronic inflammation) in awake or anaesthetized rodents and pigs. Preclinical in-vivo studies are performed in cooperation with the Institute for Biomedical Research at the Medical University of Graz.
We investigate intended effects of your drug and potential side effects directly in the skin by applying a formulated drug via the intended route (e.g. subcutaneous, oral, topical). We use dOFM or microdialysis probes in the dermis and continuously sample dermal interstitial fluid. Multiple probes per application site allow for an efficient study design which delivers a large amount of reliable data while using only a relatively small number of subjects in PK/PD studies.
Complementary techniques include tape-stripping and specialized in-vivo biopsies to obtain cross-sectional dermal PK profiles.